Van de Ven Double Halts Everton's Run at New Stadium
Micky van de Ven became the initial backline player to score twice in a Premier League game for Spurs since the Belgian defender in March 2013.
At a glance
Micky Van de Ven nods home twice in opening period
Everton's Jake O'Brien has equalizer ruled after video check
Pape Matar Sarr scores third in 89th minute
The defeat is Everton's first at their new ground
Micky van de Ven found the net on two occasions as Tottenham extended their winning streak on the road in the top division and delivered Everton their first defeat at Hill Dickinson Stadium.
The Toffees were undefeated in their last five matches at their new ground at Bramley-Moore Dock, having left Goodison Park behind after more than a century at the conclusion of last season.
But Tottenham's leader Van de Ven pounced on two occasions from set-pieces in the first half to place their impressive record at risk, and they were failed to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward Richarlison - nodded in a final goal to seal the victory.
Jake O'Brien thought he had equalized the tally a short while after the defender's opener, directing a bullet header past the Spurs keeper from an Everton corner.
Beto, meanwhile, failed to convert a handful of opportunities, while the Italian goalkeeper made a succession of excellent stops to ensure the London club went five away games unbeaten in the English top flight.
But the video assistant referee intervened, advising Craig Pawson to review the score on the screen and the referee ruled that Jack Grealish and Iliman Ndiaye were in offside positions and had impeded with the Tottenham goalkeeper.
The win moves Thomas Frank's team into third place in the Premier League, a handful of points off local foes and leaders the Gunners.
The Merseyside club remain 14th and are six points clear of the relegation zone.
Spurs breakdown: Van de Ven excels in role at each end of the field
Following a uninspiring weekday display in the European competition against Monaco, where they mustered a mere attempts on goal, the manager opted for the French striker in attack instead of former Toffees player the Brazilian.
The summer signing was failed to make much of an impact before being substituted for the substitute after 60 minutes on the pitch, but it emerged he proved unnecessary in the end.
Defender Van de Ven transformed into an offensive threat to be reckoned with.
Spurs' opening strike came from a cleverly executed set-piece play, with the midfielder directing the ball toward the six-yard box for an unmarked the defender to head home.
And Ven de Ven - stepping up as captain in Cristian Romero's absence - notched his second in added time as he rose above Jordan Pickford to head home.
Van de Ven was just as outstanding in defensive duties, combining well with his defensive colleague as the duo dealt superbly with the 34 crosses sent their way by Everton.
Toffees breakdown: Toffees missing striker's instinct
Everton's new home had been a fortress, but it appears the novelty may have worn off slightly and fans headed to the gates after the midfielder's third for Spurs.
The end in the team's unbeaten home run will not be a major worry for David Moyes, but their attacking woes will be.
Beto and Thierno Barry - the Everton's two established centre-forwards - had scored just one league goal between them before the weekend's match.
And they were unable to contribute to that miserable tally on a damp and dreary evening on Merseyside.
Beto's performance was epitomized when he opted to overhead kick a golden opportunity from near the goal, despite having space and opportunity to reposition for a simpler shot that would have challenged the keeper.
The substitute, too, was unable to make an impact after replacing the starter in the 65th minute.
It wasn't for a shortage of opportunity. The majority of the home side's offensive moves came through the winger and Ndiaye, who relentlessly whipped threatening crosses into the Spurs box.
Upcoming fixtures for both teams?
The Toffees: Moyes' men head to Sunderland in the Premier League on early November at 20:00 GMT.
Tottenham: Spurs go to St James' Park on Wednesday, 29 October for their fourth-round Carabao Cup tie against the Magpies.